Development and validation of stability indicating RP-HPLC method for estimation of Perindopril Erbumine and Indapamide in bulk and pharmaceutical dosage form

Background: Perindopril erbumine (PE) and Indapamide (IND) in combination were proven to have a synergistic antihypertensive impact when compared with the use of each component alone. Objectives: Therefore, new simple, selective, precise, stability indicating RP- HPLC method for analysis both bulk pharmaceutical formulation has been developed validated. Methods: RP ‑ method, Younglin (S.K.) Gradient System UV Detector C18 column 250mm x 4.6 mm i. d. 5μm particle size acetonitrile 70+ water OPA 30 was used as mobile phase method. The detection wavelength 215 nm flow rate 1 ml/min. Results: In retention time found be 5.4833 min 9.4500min. validated according ICH guidelines. linearity, precision, range, robustness within limits specified by Conclusion: Hence accurate, economic reproducible. forced degradation studies proved power